Sites need to produce accurate, actionable data, but how can they focus on quality when bogged down with administrative tasks? To keep trials on track, you need superior at-the-source data collection, streamlined workflows, and real-time visibility that lighten site burden while driving protocol compliance. You need the best eSource in clinical trials — which is clearly CRIO.  

A screenshot of the CRIO New eSource “Standard Vitals” page for subject X2877925, Visit 1 (Screening) at 10:00 AM, logged in as Tara Sheffield.
Header:
Top bar shows subject ID (“X2877925”), subject initials and ID (“AH, 86571001”), visit (“Visit 1 Screening”), investigator name (“Dr. Josh Norman”), and user (“Tara Sheffield”), with a “View Legend” button on the right.
Left sidebar (vertical nav):
Tabs (white text on dark blue):
Informed Consent (with green checkmark)
Standard Vitals (selected)
Demographics
Urine Pregnancy Test
Physical Exam
Physical Exam Payable
Concomitant Medications
Adverse Events
Complete Visit
Main content area:
Title: “Standard Vitals”
Instructions box (pale yellow) reads: “Patient should take blood pressure after 5 minutes in sitting position.”
Temperature fields:
Temperature (F): 98
Temperature (C): 36.7
Temp Method: Option “Oral” is selected.
Right sidebar (Add Progress Note panel):
Title: “Add Progress Note – Standard Vitals”
Note text: “Vitals collected per protocol prior to IP administration. BP, HR, RR, Temp, and SpO₂ recorded. Participant was seated for 5 minutes prior to measurements. No abnormalities noted.”
Draft status: “Draft started on 21-MAY-2025 3:23 PM EDT”
Buttons at bottom: “Save Draft,” “Publish,” and “Cancel”

CRIO is the only eSource platform with central and local site offerings tailored to sponsors, contract research organizations (CROs), and sites. 

For over a decade, clinical research sites, site networks, and academic centers around the globe have used CRIO’s eSource to improve efficiency and guide protocol compliance, delivering higher quality data and fewer protocol deviations.  

CRIO is the leading eSource in clinical trials, delivering 40% higher enrollment, 40% faster startup, and 40% fewer protocol deviations.

eSource Platform

Created by a team of clinical research experts to help sites manage their study protocols from start to finish, our platform helps sites compliantly and efficiently capture source data.  

eSource platform screen

A screenshot of the CRIO web app in the “Data Review” → “Review & Lock” view for the “PLAYGROUND-123 Training” trial. The top nav shows the CRIO logo, a “Master” dropdown, “TRIALS” and “ORGANIZATION” headers, and the user avatar labeled “Amelia Tian.” Below it, the “Data Review” tab is active, with a small multicolor legend and filters for “All” vs. “Need Review Only,” a “Show Read Only” checkbox, and a Subject ID search field. The main panel is expanded for “120 – Amelia Tian – Reviewer Test Site 1” and displays a table with columns: Subject ID, Status, Description, Completed On, Open Queries, and Actions. Three subjects appear: z123 (locked icon) | In Screening | green lock icons for LOG and STATUS, yellow lock icons for Screening and Randomization | dates “31-MAR-2023 12:15 PM EDT” and “03-APR-2024 5:57 PM EDT” | 0 queries | no action YS | In Screening | green square icon for STATUS, yellow square for Screening | date “08-APR-2025 3:21 PM EDT” | 1 query | “Review” link test | Enrolled | green square icon for STATUS | – | 0 queries | “Review” link

EDC Integration

Integrate Central eSource with other third-party EDC systems or use CRIO’s Reviewer EDC for full, native integration. 

Publishing

Centrally create, manage, and publish eSource templates across multiple sites.

A screenshot of the CRIO Publisher portal, showing version management in the “Configure” tab for version 4 – MAY2025. Logged in as “test.”

Header:

Top bar shows the CRIO logo, dropdown labeled “Publisher” (with an orange dot), and username “test.”

Main navigation tabs:

Overview

Subjects

To-dos

Progress Notes

Comments

Files

Logs

Configure (selected with an orange underline)

Sub-navigation tabs (blue text):

Visits

Procedures (selected)

Reminders

Subject Status

Left column – Available Sites list (scrollable):

Test Organization – Cambridge MA

CRIO CX GAAP – Cambridge, MA

CRIO Connect Test Organization 9 – Cambridge, MA

CX Test: New eSource – Cambridge, MA

Training Organization – …

Main content area:

Three horizontal cards representing procedure versions:

“2 – End Draft” (grayed out, zero sites)

“3 – 27JAN25” (Published, 1 site – CRIO Cambridge, with procedures “Welcome to CRIO – eSource” and “Welcome to CRIO – AC Demo”)

“4 – MAY2025” (orange, labeled Draft with 0 sites assigned)

Test Organization – A Test Site

Welcome to CRIO – Investigator Training

Welcome to CRIO – eSource

A circular “+” button appears at far right of the version cards row.

Reporting

CRIO offers a comprehensive suite of standard reports, a flexible tool for creating reports within the CRIO platform, a custom report development service, and direct data access that allows clients to use their own business intelligence tools.

Get the eSource you need and watch your studies succeed.

Schedule a Demo