End-to-End Clinical Research Technology for Sites

End-to-End Clinical Research Technology for Sites

Why Is CRIO the Platform of Choice for High-Performing Research Sites?

CRIO is the all-in-one eSource and CTMS platform for clinical research sites to streamline operations and data capture.

CRIO is the all-in-one eSource and CTMS platform for clinical research sites to streamline operations and data capture. You need to produce reliable, protocol-driven data, but how can you focus on quality when you’re bogged down with administrative details and manual tasks? There’s a clinical research technology that collects source data in real time and enables remote monitoring, optimizing your performance with streamlined operations, eRegulatory management, 24/7 customer service, and real-time visibility. It’s clearly CRIO.

 

A dashboard screenshot under the home icon. Header “My Dashboard” with tabs “Visits to Complete,” “Visits to Sign Off,” and “Queued Jobs.” Under “Visits to Complete,” it lists “Today’s Remaining Visits (1)” for 18 Apr with one entry at 7:30 AM marked READY. Below “Today’s Processed Visits (2)” shows two visits marked PARTIALLY COMPLETE. Further down under “Overdue Visits (6)” an entry dated 17 Mar is labeled NOT YET STARTED. On the right is “My Tasks” in a pink box showing counts for Unresolved Comments, Draft Progress Notes, Assigned Documents, and Owned Documents, plus a “Prime Study Tasks” summary.

  • 33% time savings

  • 40% higher enrollment

  • 40% fewer protocol deviations

  • 70% lower audit risk

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Using CRIO, our site saved so much time. We were the top enroller on our RSV vaccine study, randomizing 388 patients in 6 months, 85% of them African American.

Hisham Atriss
President/Founder, Vida Clinical Studies

Our CRAs love CRIO – they say it makes their monitoring much easier to do. With the built-in queries, we can respond to their questions right away. Unlike other remote monitoring solutions, we don’t have to stand by the scanner spending hours uploading documents.

Joel Ebuh
CEO, Gadolin Research

In the exam room, the system is like an app, not a cumbersome program. It has the look and feel of efficiency, which is what you want.

David Scott
Owner, Palm Beach Research
SEE CRIO IN ACTION

Why Is CRIO’s Clinical Research Technology Better for Performance?

CRIO is an eSource platform built by a former site owner to reduce administrative burden and drive better performance at clinical research sites. CRIO makes it all easier.

Build Quality at the Source

Highly configurable, easy-to-build eSource templates automate the protocol, incorporate real-time alerts, and run built-in checks to stop mistakes before they happen.  

Optimize Operations

  • Single-point data capture reduces duplicative work and administrative burden, improving enrollment, accelerating startup, and allowing you to focus on patients  
  • Integrated finances keep receivables up to date and streamline invoices and payments  
  • eRegulatory solution eliminates paper binders, reduces deviations, and enables remote collaboration 
A photograph of a MacBook Pro open on a white desk, showing a dark-themed clinical eSource “Labs” form on its screen. The interface header reads “New eSource” with subject “Demo Subject 001” and “Visit 5 Treatment” by “Amelia Tian.” Below, it displays instructions (“Blood Draw Instructions from Protocol”), radio buttons asking “Were labs collected at this visit?” (Yes selected) and “Has the subject fasted for at least 8 hours before collection?” (Yes selected), and checkboxes for tests collected (“Chemistry (fasted),” “Hematology (fasted),” “Hepatitis Screen,” “Biomarkers,” “Other, specify”). A small potted plant sits behind the laptop, a tablet lies closed to the right, and stylized blue and orange hexagons decorate the blurred window background.

​CRIO-powered sites out-enroll others by 40% and have 2x the patient diversity

A middle‑aged woman with curly brown hair pulled back, wearing black‑frame glasses and a light button‑up shirt, sits on a gray sofa in a bright, modern living room. She holds a black smartphone in both hands, tapping the screen with her right index finger, and appears focused. Two semi‑transparent hexagon graphics—one orange outline behind her, one solid blue to her right—float in the background.

Quickly Recruit & Schedule

  • Integrated patient recruitment solutions send text blasts, enable interactive prescreening questionnaires, and pull web leads directly into the system and more  
  • Automated window tracking schedules visits and pre-programs appointment reminders to keep patient visits on track 
Female doctor with a stethoscope around her neck looking at a laptop screen in a bright medical office, appearing focused and content.

Why Do Clinical Trial Sites Choose CRIO?

3,000 sites use the CRIO platform on 6,000+ protocols for over 3000 sponsors in over 30 different countries. 

Find Out What We Can Do for You

Go Further, Faster, With CRIO

Our clinical research technology seamlessly integrates with leading site service providers, patient recruitment and retention vendors, and other eClinical technology providers, further optimizing your operations.  

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Frequently Asked Questions About CRIO Central eSource for Sites

CRIO is the leading all-in-one eSource and CTMS platform built specifically for clinical research sites. Unlike generic software adapted for research, CRIO was designed from the ground up to reflect how sites actually work, combining electronic source documentation, regulatory binder management, visit scheduling, billing, and participant tracking in a single, unified system. Sites no longer need to juggle disconnected tools or re-enter data across platforms. With CRIO, everything lives in one place, giving your team a single source of truth from screening through closeout.

CRIO enables coordinators to capture source data directly at the point of care using electronic source (eSource) forms built to match each protocol. Rather than recording observations on paper and transcribing them later, staff document findings in real time, eliminating dual-entry, reducing transcription errors, and creating a contemporaneous, time-stamped record. Data flows automatically into the study record, keeping source documentation complete and audit-ready without added steps.

CRIO automates the workflows that consume the most coordinator time. Visit schedules are built from the protocol, task lists guide staff through each visit, regulatory documents are organized automatically, and invoicing is generated from completed visit data. The result is a leaner administrative workload that lets your team focus on participants and science rather than paperwork.

Every action in CRIO is logged with a time-stamped, user-attributed audit trail that meets FDA 21 CFR Part 11 requirements. Source data is captured contemporaneously and linked directly to the protocol, removing the gaps and inconsistencies that commonly arise from paper or hybrid processes. Regulatory binders are maintained automatically, expiration dates are tracked, and nothing falls through the cracks. When an auditor or monitor arrives — in person or remotely — your documentation is complete, organized, and instantly accessible.

CRIO is the all-in-one eSource and CTMS platform purpose-built for clinical research sites — combining at-the-source data collection, streamlined operations, 24/7 customer service, and real-time visibility in a single integrated system. Designed by clinical research experts who understand what sites need to perform better, CRIO helps sites collect source data in real time, eliminate administrative burden, and satisfy sponsor data quality requirements. Sites using CRIO see 33% time savings, 40% higher enrollment, 40% fewer protocol deviations, and 70% lower audit risk. It’s clearly CRIO.