eClinical Systems for Decentralized Clinical Trials

Your End-to-End Solution for Paper-Free Compliance

It’s simple: You can’t adequately manage and oversee decentralized clinical trials (DCTs) or hybrid trials with paper documentation. But there’s an eClinical system that eliminates paper and reduces variability to ensure complete protocol compliance and optimal data quality. It’s clearly CRIO.

40% fewer protocol deviations
70% lower audit risk
40% higher enrollment

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Intuitive eClinical System Enabling Standardized, Efficient Operations

From virtual sites and meta sites to home nursing, pharmacies, mobile sites, and other nontraditional models, CRIO is the eSource software solution you need to save time and money without compromising quality.

Eliminate Paper

Capture and review site source data and informed consents electronically and remotely
Centralize patient recruitment, regulatory compliance, and data collection and review
Empower staff at all levels and locations with an interactive, AI-powered CRIO help center

A screenshot of the CRIO eSource “Informed Consent with Re-Consent” page in read-only mode. At top is the dark app header showing “3:04 PM,” “Subject Status,” “Visit 1 Screening,” and user “Amelia Tian.” The left sidebar lists form sections (Formatting, Subject Only Consent, etc.) with “Informed Consent with Re-Consent” highlighted. In the main panel a lavender “READ-ONLY MODE” banner sits above the title. Below, an Instructions box prompts to “ENTER INSTRUCTIONS FROM PROTOCOL” and notes use of “Informed Consent Form v2.0 15-Oct-2024.” Underneath are consent questions with radio-button options for “Yes” or “No” and a disabled date/time picker for “Date/Time of signature,” followed by further “Yes/No” questions about timing of consent and whether a copy was provided.

CRIO’s live, 24/7 customer support chat has a 97% satisfaction rating.

A screenshot of the CRIO eSource “Configure” tab on a study called “New eSource Demo,” showing the “Procedures” configuration screen. Across the top is a row of colored visit-phase headers—“Pre” (lavender), “Screening” (pale yellow), “Treatment” (light blue, spanning sub-columns “Baseline,” “Treatment,” “First eDiary,” “Treatment,” “Second eDiary”), and “Followup” (light green). Down the left are procedure names in blue text (“Recruitment Questionnaire” with a user-silhouette icon, “Formatting,” “Subject Only Consent,” “Informed Consent with Re-Consent,” “SPANISH Version–Informed Consent with R…”). Each cell at the intersection of a procedure and a visit phase contains either a greyed-out checkmark (inactive) or a solid green checkmark (active), indicating which procedures are scheduled for which visits. A “View Audit Log” link sits at top right of the grid.

Reduce Variability

Standardize protocol templates and data collection across sites — from mobile units to in-home nurses and everything in between

Improve Oversight

Ensure protocol and good clinical practice (GCP) compliance from any location with fully remote monitoring
Safeguard data quality with electronic data entry and real-time compliance alerts

A screenshot of the CRIO eSource Vitals data‐entry screen, overlaid by a centered alert box with a blue exclamation icon that reads, “Five minutes has not elapsed from position. Please wait further.” In the background you can just make out the Vitals form fields (Subject position time, Vitals time, Temperature °F/°C, Temp method) and the left‐hand navigation with “Vitals” highlighted.

A screenshot of the CRIO eSource “Labs” form for “Demo Subject 001” at “Visit 5 – Treatment,” recorded at 7:00 AM by Amelia Tian. On the left, the “Labs” section is highlighted in a dark sidebar beneath consent and Ht/Wt/BMI sections. The main panel is titled “Labs” and shows an Instructions box reading “Blood Draw Instructions from Protocol.” Below it:

Were labs collected at this visit? Radio buttons with “Yes” selected

Has the subject fasted for at least 8 hours before collection? Radio buttons with “Yes” selected

Select test(s) collected: Checkboxes with “Chemistry (fasted),” “Hematology (fasted),” and “Hepatitis Screen” checked; “Biomarkers” and “Other, specify” left unchecked.

Integrate With Your Preferred Systems

CRIO’s platform works with DCT vendor systems to further streamline your operations.

Selecting CRIO has allowed us to introduce a more efficient and secure process for source data capture during home health visits that facilitates real-time source data access for sites and CRAs, all at a really reasonable price point. The team at CRIO have also been exceptional to work with, providing swift and detailed answers to all questions throughout the onboarding and implementation phase. We’re looking forward to continuing the partnership!

Tom Brazier
Director, Decentralised Clinical Solutions and Vendor Management, mdgroup

Using CRIO for our clinical trials has been truly transformational for our site. As a mobile site, we require flexibility in how we deliver trials and manage document storage, and CRIO has perfectly addressed these needs. The platform’s adaptability has streamlined our processes, making it easier to manage data, communicate with stakeholders, and stay compliant. We are grateful for the positive impact CRIO has had on our operations, and we look forward to continued success with this innovative tool. Thank you!

Melissa Reidy
Senior Project Manager, Heart of Australia

We chose CRIO to streamline the oversight and standardisation of operations across our community-based clinical site network. When looking for a site CTMS, we were drawn to CRIO’s intuitive user experience, which we felt would perfectly suit our community research teams, embedding quality by design across our organisation. The platform also stood out for the CRIO team’s implementation support, offering us a partnership approach as we grow our research portfolio.

Claire Sears
Head of Business Optimisation, EMS Healthcare