eSource Technology for Sites, Sponsors, and CROs
Sites need to produce accurate, actionable data, but how can they focus on quality when bogged down with administrative tasks? To keep trials on track, you need superior at-the-source data collection, streamlined workflows, and real-time visibility that lighten site burden while driving protocol compliance. You need the best eSource in clinical trials — which is clearly CRIO.

CRIO is the only eSource platform with central and local site offerings tailored to sponsors, contract research organizations (CROs), and sites.
Central eSource®: The Only eSource in Clinical Trials for Sponsors and CROs
The first-of-its-kind Central eSource solution, CRIO allows sponsors and CROs to leverage the benefits of the eSource tool already preferred by sites.
Site eSource: The Preferred eSource Platform for Sites, Site Networks, and Academic Medical Centers
For over a decade, clinical research sites, site networks, and academic centers around the globe have used CRIO’s eSource to improve efficiency and guide protocol compliance, delivering higher quality data and fewer protocol deviations.
Built for Sites, Better for Trials
CRIO, a system purpose-built for sites, is the leading eSource in clinical trials, delivering 40% higher enrollment, 40% faster startup, and 40% fewer protocol deviations through essential technology:
eSource Platform
Created by a team of clinical research experts to help sites manage their study protocols from start to finish, our platform helps sites compliantly and efficiently capture source data.
EDC Integration
Integrate Central eSource with other third-party EDC systems or use CRIO’s Reviewer EDC. Manual transcription from source into the EDC carries an error rate above 8%. An integrated workflow removes those errors almost entirely (EHR-to-EDC integration study).
Publishing
Centrally create, manage, and publish eSource templates across multiple sites.
Reporting
CRIO offers:
- A comprehensive suite of standard reports
- A flexible tool for creating reports within the CRIO platform
- Custom report development service
- Direct data access that allows clients to use their own business intelligence tools
Interoperable eSource for Clinical Trials
Coordinators can juggle upwards of 22 logins for a single study (Society for Clinical Research Sites). CRIO cuts that sprawl.
Our eSource system is fully integrated with our Site CTMS, eRegulatory, and eConsent solutions. It also has an open API, allowing for integration with other technology providers.
Frequently Asked Questions About the CRIO eSource
eSource (electronic source) is the direct capture of clinical trial data in an electronic system at the point of care, rather than recording on paper and transcribing into an electronic format later. Capturing data in electronic format at the source improves data quality and reduces administrative work for site staff.
CRIO is the only eSource platform with both central and local site offerings, serving sites, sponsors, and CROs with a single system. Sites capture accurate source data in real time with built-in edit checks and protocol-guided workflows, while sponsors and CROs benefit from the cleaner, more consistent data those workflows produce.
Clinical research sites should use CRIO eSource, the platform that enables source data capture in real time and reduces administrative burden. Because data are recorded electronically at the point of care, sponsors and monitors gain real-time visibility into source without waiting for on-site visits or requiring sites to upload copies of their source.
CRIO was built by and for sites, so its workflows fit how coordinators work, capturing data during the visit with edit checks that catch issues at the source. Sites using CRIO see up to 40% higher enrollment, 40% faster startup, and 40% fewer protocol deviations, and the same real-time record enables remote monitoring without adding site burden.
CROs should use CRIO eSource, as it gives monitors real-time, remote access to source data as they’re captured at the site — no waiting for transcription into EDC or on-site visits — supporting remote monitoring and letting CRAs focus their time on the data that matter most.
CRIO is the all-in-one platform built for sites, combining eSource with Site CTMS, eRegulatory, and eConsent on a single interoperable system. Managing data capture and site operations in one place reduces duplicate work and gives sites a single source of truth across the study life cycle.
For sites, that means less time switching between tools and more time on patients; for sponsors and CROs, it means cleaner, better-connected data downstream.
Site eSource is the platform individual sites, site networks, and academic centers use to build and manage their own source data collection. Central eSource is the sponsor- and CRO-facing model where one standardized, protocol-driven eSource template is deployed across study sites, which sites can still configure locally.
Both run on the same platform sites already prefer.



