Sites need to produce accurate, actionable data, but how can they focus on quality when bogged down with administrative tasks? To keep trials on track, you need superior at-the-source data collection, streamlined workflows, and real-time visibility that lighten site burden while driving protocol compliance. You need the best eSource in clinical trials — which is clearly CRIO.  

A screenshot of the CRIO New eSource “Standard Vitals” page for subject X2877925, Visit 1 (Screening) at 10:00 AM, logged in as Tara Sheffield.Header:Top bar shows subject ID (“X2877925”), subject initials and ID (“AH, 86571001”), visit (“Visit 1 Screening”), investigator name (“Dr. Josh Norman”), and user (“Tara Sheffield”), with a “View Legend” button on the right.Left sidebar (vertical nav):Tabs (white text on dark blue):Informed Consent (with green checkmark)Standard Vitals (selected)DemographicsUrine Pregnancy TestPhysical ExamPhysical Exam PayableConcomitant MedicationsAdverse EventsComplete VisitMain content area:Title: “Standard Vitals”Instructions box (pale yellow) reads: “Patient should take blood pressure after 5 minutes in sitting position.”Temperature fields:Temperature (F): 98Temperature (C): 36.7Temp Method: Option “Oral” is selected.Right sidebar (Add Progress Note panel):Title: “Add Progress Note – Standard Vitals”Note text: “Vitals collected per protocol prior to IP administration. BP, HR, RR, Temp, and SpO₂ recorded. Participant was seated for 5 minutes prior to measurements. No abnormalities noted.”Draft status: “Draft started on 21-MAY-2025 3:23 PM EDT”Buttons at bottom: “Save Draft,” “Publish,” and “Cancel”

CRIO is the only eSource platform with central and local site offerings tailored to sponsors, contract research organizations (CROs), and sites. 

For over a decade, clinical research sites, site networks, and academic centers around the globe have used CRIO’s eSource to improve efficiency and guide protocol compliance, delivering higher quality data and fewer protocol deviations.  

CRIO​, a system purpose-built for sites,​ is the leading eSource in clinical trials, delivering 40% higher enrollment, 40% faster startup, and 40% fewer protocol deviations through essential technology:

eSource Platform

Created by a team of clinical research experts to help sites manage their study protocols from start to finish, our platform helps sites compliantly and efficiently capture source data.  

eSource platform screen

A screenshot of the CRIO web app in the “Data Review” → “Review & Lock” view for the “PLAYGROUND-123 Training” trial. The top nav shows the CRIO logo, a “Master” dropdown, “TRIALS” and “ORGANIZATION” headers, and the user avatar labeled “Amelia Tian.” Below it, the “Data Review” tab is active, with a small multicolor legend and filters for “All” vs. “Need Review Only,” a “Show Read Only” checkbox, and a Subject ID search field. The main panel is expanded for “120 – Amelia Tian – Reviewer Test Site 1” and displays a table with columns: Subject ID, Status, Description, Completed On, Open Queries, and Actions. Three subjects appear: z123 (locked icon) | In Screening | green lock icons for LOG and STATUS, yellow lock icons for Screening and Randomization | dates “31-MAR-2023 12:15 PM EDT” and “03-APR-2024 5:57 PM EDT” | 0 queries | no action YS | In Screening | green square icon for STATUS, yellow square for Screening | date “08-APR-2025 3:21 PM EDT” | 1 query | “Review” link test | Enrolled | green square icon for STATUS | – | 0 queries | “Review” link

EDC Integration

Integrate Central eSource with other third-party EDC systems or use CRIO’s Reviewer EDC. Manual transcription from source into the EDC carries an error rate above 8%. An integrated workflow removes those errors almost entirely (EHR-to-EDC integration study).  

Publishing

Centrally create, manage, and publish eSource templates across multiple sites.

A screenshot of the CRIO Publisher portal in the “Configure” tab, showing version publishing status for procedures. Version 1.0 – 7Apr2023 is queued for publishing.Header:Top bar includes navigation tabs:OverviewSubjectsTo-dosProgress NotesCommentsFilesLogsConfigure (selected with orange underline)Sub-navigation tabs (blue text):VisitsProcedures (selected)RemindersSubject StatusSuccess banner (green with checkmark icon):“V1 – Version 1.0 – 7Apr2023 queued for publishingFor larger queues of sites, publishing may take a few minutes”Dismiss “X” icon on far rightLeft column – Available Sites list (scrollable):Test Organization – API discussionTest Organization – Clinical SiteTest Organization – Miskatonic UniversityMain content area:Single version tile:“V1 – Version 1.0 – 7Apr2023” (orange background, labeled “Published”)Site count: “2” in small circle on upper right of the tileSites listed:Test Organization – Training (2Mar2023)Test Organization – Cambridge, MACircular “+” button at far right of the version tile row

Reporting

CRIO offers:

  • A comprehensive suite of standard reports 
  • A flexible tool for creating reports within the CRIO platform 
  • Custom report development service 
  • Direct data access that allows clients to use their own business intelligence tools 

eSource (electronic source) is the direct capture of clinical trial data in an electronic system at the point of care, rather than recording on paper and transcribing i​nto an electronic format​​ later. Capturing data​ in electronic format​ at the source ​improves data quality and reduces administrative work for site staff​​. 

CRIO is the only eSource platform with both central and local site offerings, serving sites, sponsors, and CROs ​with​​ a single system. Sites capture accurate source data in real time with built-in edit checks and protocol-guided workflows, while sponsors and CROs benefit from the cleaner, more consistent data those workflows produce. 

Clinical research sites should use CRIO eSource, the platform that enables source data capture in real time and reduces administrative burden. Because data are recorded electronically at the point of care, sponsors and monitors gain real-time visibility into source without waiting for on-site visits​ or requiring sites to upload copies of their source​. 

CRIO was built by and for sites, so its workflows fit how coordinators work, capturing data during the visit with edit checks that catch issues at the source. Sites using CRIO see up to 40% higher enrollment, 40% faster startup, and 40% fewer protocol deviations, and the same real-time record enables remote monitoring without adding site burden.

CROs should use CRIO eSource, as it gives monitors real-time, remote access to source data as they’re captured at the site — no waiting for transcription​ into EDC​ or on-site visits — supporting remote monitoring and letting CRAs focus their time on the data that matter most. 

CRIO is the all-in-one platform built for sites, combining eSource with Site CTMS, eRegulatory, and eConsent on a single interoperable system. Managing data capture and site operations in one place reduces duplicate ​work​​     ​ and gives sites a single source of truth across the study life cycle. 

​​For sites, that means less time switching between tools and more time on patients; for sponsors and CROs, it means cleaner, better-connected data downstream.

Site eSource is the platform individual sites, site networks, and academic centers use to build and manage their own source ​data ​collection. Central eSource is the sponsor- and CRO-facing model where one standardized, protocol-driven eSource template​ is deployed​ across study sites, which sites can still configure locally. 

Both run on the same platform sites already prefer.

Get the eSource you need and watch your studies succeed.

Schedule a Demo