Your Central eSource System

Leverage Site eSource Technology to Improve Trial Quality

With most eSource solutions, clinical trial sites create their own source templates from complex protocols and eCRF guidelines, use the templates to collect source data in disparate paper and electronic systems, and then manually transcribe the data into the electronic data capture system (EDC) — inevitably leading to delays and poor data quality. How can you get immediate visibility and better data without adding more work for your sites? There’s a Central eSource system that does it all. It’s clearly CRIO.

Find out how your next trial can benefit from CRIO Central eSource.  

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A screenshot of the CRIO web app in the “Data Review” → “Review & Lock” view for the “PLAYGROUND-123 Training” trial. The top nav shows the CRIO logo, a “Master” dropdown, “TRIALS” and “ORGANIZATION” headers, and the user avatar labeled “Amelia Tian.” Below it, the “Data Review” tab is active, with a small multicolor legend and filters for “All” vs. “Need Review Only,” a “Show Read Only” checkbox, and a Subject ID search field. The main panel is expanded for “120 – Amelia Tian – Reviewer Test Site 1” and displays a table with columns: Subject ID, Status, Description, Completed On, Open Queries, and Actions. Three subjects appear: z123 (locked icon) | In Screening | green lock icons for LOG and STATUS, yellow lock icons for Screening and Randomization | dates “31-MAR-2023 12:15 PM EDT” and “03-APR-2024 5:57 PM EDT” | 0 queries | no action YS | In Screening | green square icon for STATUS, yellow square for Screening | date “08-APR-2025 3:21 PM EDT” | 1 query | “Review” link test | Enrolled | green square icon for STATUS | – | 0 queries | “Review” link

Automate Data Flow From eSource to EDC

​​With the CRIO​ Central e​​Source system, you develop a central source template and publish it to your sites, who can then configure the template to comply with local requirements while leaving core data fields intact. This unique process reduces site burden, accelerates startup, and standardizes data collection to improve overall quality. 

By reducing administrative work and preventing errors, CRIO Central eSource delivers 40% higher enrollment, 40% faster time to EDC entry, 20% fewer protocol deviations, and a 90% increase in monitoring productivity.  

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The ​CRIO Central ​​eSource System vs. Everyone Else 

Without CRIO Central eSource

Different protocol interpretations lead to variations in source templates and data collection

Sites must create the whole source template, slowing study startup

Manual EDC entry causes errors, delays, and extra work for sites and requires sponsors and CROs to perform source data verification (SDV)

A mix of source data collection mechanisms with varying accessibility for sponsors and CROs

With CRIO Central eSource

One centralized template ensures key safety and endpoint data are captured the same way across all sites

Templates are standardized with key data points but can still be configured by sites to fit their processes

Pre-mapped eSource variables feed data directly into the EDC

Sponsors and CROs have real time, fully remote access to source data across all sites

Got a question about how Central eSource can optimize your study?

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Central eSource Features

Central eSource allows sponsors and CROs to benefit from the technology sites are already using.  

eSource to EDC Data Flow

Eliminate manual transcription and SDV with integration to Reviewer EDC — our native EDC system — or a third-party EDC system.   

Explore Your eSource to EDC Options
A screenshot of the CRIO web application’s Data Review view for a single site (“120 – Amelia Tian – Reviewer Test Site 1”) in the “PLAYGROUND-123 Training” study. At the top is a dark blue header bar showing the CRIO logo on the left, a “Master” workspace selector, navigation links for “TRIALS” and “ORGANIZATION,” and the user avatar/name (“Amelia Tian”) on the right. Below that, a white toolbar displays the study name (“PLAYGROUND-123 Training”) with a site selector dropdown. Underneath, a secondary tab bar has five tabs: Data Review (selected, with an orange underline), Queries, Files, Medical Coding, and Users. Within Data Review there are sub-tabs “Review & Lock” (selected), “Progress Notes,” and “Export/Print.” A small legend shows colored lock icons and thumbs-up icons with a “View Legend” link. To the right is a “Want to Lock a Subject?” help link. Beneath, a blue filter bar has a “View” label with “All” (orange) and “Need Review Only” buttons, a “Show Read Only” checkbox, and a Subject ID search field. The main panel is a table with columns: Subject ID, Status, Description, Completed On, Open Queries, and Actions. It shows three rows: Subject ID “z123” has a red closed-lock icon, status “In Screening” (blue link), in Description two green-lock items labeled “LOG” and “STATUS” with no completion dates, and two yellow-lock items “Screening” (completed 31-MAR-2023 12:15 PM EDT) and “Randomization” (03-APR-2024 5:57 PM EDT). Open Queries is 0; Actions column is blank. Subject ID “YS” has no lock icon, status “In Screening,” Description shows a green-lock “STATUS” (no date) and a yellow-lock “Screening” (08-APR-2025 3:21 PM EDT). Open Queries is 1; Actions shows a “REVIEW” link in green. Subject ID “test” has no lock icon, status “Enrolled,” Description shows a green-lock “STATUS” (no date). Open Queries is 0; Actions shows a “REVIEW” link.

A screenshot of the Looker “Explore” interface with an “Add Filter” modal open in the center. Behind it you can see the Looker logo at top left, a “Start typing to search” bar, and the “Explore” sidebar showing field categories (“Forecast,” “Clinical Trial,” “Organization,” etc.). The modal is titled “Add Filter” with a search-fields input at the top. Underneath a collapsible list shows: Clinical Trial (collapsed) Forecast (expanded) with items: Currency Symbol Is Actual Revenue (Yes / No) Is for Existing Subject (Yes / No) Number of Forecasted Subjects Study Visit Key Subject Visit Forecast Key (Back End) Visit Date (collapsed) Below, individual forecast fields in orange: Total Count (Line Items), Total Holdback, Total Revenue At the top right of the page, grayed behind the modal, is a “Time Zone: America – New York” selector and a “Run” button.

Reporting

CRIO offers a comprehensive suite of standard reports, a flexible tool for creating reports within the CRIO platform, a custom report development service, and direct data access that allows you to use your own business intelligence tools. 

Learn More About Reporting

Publishing

Centrally create, manage, and publish eSource templates across multiple sites.

A screenshot of the CRIO Publisher portal in the “Configure” tab, showing version publishing status for procedures. Version 1.0 – 7Apr2023 is queued for publishing. Header: Top bar includes navigation tabs: Overview Subjects To-dos Progress Notes Comments Files Logs Configure (selected with orange underline) Sub-navigation tabs (blue text): Visits Procedures (selected) Reminders Subject Status Success banner (green with checkmark icon): “V1 – Version 1.0 – 7Apr2023 queued for publishing For larger queues of sites, publishing may take a few minutes” Dismiss “X” icon on far right Left column – Available Sites list (scrollable): Test Organization – API discussion Test Organization – Clinical Site Test Organization – Miskatonic University Main content area: Single version tile: “V1 – Version 1.0 – 7Apr2023” (orange background, labeled “Published”) Site count: “2” in small circle on upper right of the tile Sites listed: Test Organization – Training (2Mar2023) Test Organization – Cambridge, MA Circular “+” button at far right of the version tile row

A screenshot of the CRIO Reviewer Dashboard, showing subject progress in the “Data Review” tab for the trial “PLAYGROUND-123 – Training,” logged in as Amelia Tian. Header: Top bar contains the CRIO logo, dropdown labeled “Master,” and navigation to “TRIALS” and “ORGANIZATION.” User icon and name: “Amelia Tian.” Trial Information: Study title: “PLAYGROUND-123 – Training” displayed in a white box below the header. Main navigation tabs: Queries Files Medical Coding Users Sub-tab (selected): Review & Lock (under “Data Review” tab) Additional options: “Progress Notes,” “Export/Print” Filters and Legend: Left side: Filter toggles for colored review statuses. Legend icon with text: “View Legend” Buttons: “View” with filters: “All” and “Need Review Only” “Show Read Only” checkbox Subject ID search box Subject Table below: Header: “120 – Amelia Tian – Reviewer Test Site 1” Columns: Subject ID Status Description Completed On Open Queries Actions Rows shown: Subject ID: z123 (red lock icon) Status: In Screening Description: green LOG, green STATUS, yellow Screening, yellow Randomization Dates: 31-MAR-2023, 03-APR-2024 Open Queries: 0 Actions: blank Subject ID: YS Status: In Screening Description: green STATUS, yellow Screening Completed: 08-APR-2025 Open Queries: 0 Actions: “REVIEW” Subject ID: test Status: Enrolled Description: green STATUS Completed: -- Open Queries: 1 Actions: “REVIEW”

Remote Monitoring

Dual database architecture allows real time data access for sponsors and CROs while protecting PHI.

Customer Service

Easily onboard and train participating sites with our site enablement team and keep studies moving after startup with high-touch customer service, 24/7 live chat, and dedicated resources. 

A sidebar live-chat widget overlaid on the app. At the top are back, menu (three dots), and minimize icons. Below is a badge with the CRIO logo, a green “online” dot, and the name “Juno – Product Expert.” A single system bubble says “Chat queued…” At the bottom is the user’s message in the input field: “Hi! Can you help me figure out how to set up security rules for my procedure?” with emoji, attachment, and send-arrow buttons. The footer reads “Powered by LiveChat.”

Smiling healthcare worker in blue scrubs using a computer at a medical facility, wearing a name badge and seated in a brightly lit room.

The Sites Have Spoken

CRIO is the eSource system of choice for sites. Why not make the most of it with Central eSource?  

See Why CRIO Is Built for Sites & Better for Your Trials

Give your sites what they need and watch your study succeed.

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