Central eSource for Sponsors

Empower Your Sites to Improve Performance and Data Quality

Visibility into clinical trial data enables the right choices at critical moments. But how can sites focus on quality when they’re bogged down with administrative work? Luckily, there’s a Central eSource that automates your protocol, embeds quality at the point of capture, and enables fully remote monitoring to improve site performance and deliver better, faster data. It’s clearly CRIO.

A screenshot of the CRIO New eSource “Standard Vitals” page for subject X2877925, Visit 1 (Screening) at 10:00 AM, logged in as Tara Sheffield.
Header:
Top bar shows subject ID (“X2877925”), subject initials and ID (“AH, 86571001”), visit (“Visit 1 Screening”), investigator name (“Dr. Josh Norman”), and user (“Tara Sheffield”), with a “View Legend” button on the right.
Left sidebar (vertical nav):
Tabs (white text on dark blue):
Informed Consent (with green checkmark)
Standard Vitals (selected)
Demographics
Urine Pregnancy Test
Physical Exam
Physical Exam Payable
Concomitant Medications
Adverse Events
Complete Visit
Main content area:
Title: “Standard Vitals”
Instructions box (pale yellow) reads: “Patient should take blood pressure after 5 minutes in sitting position.”
Temperature fields:
Temperature (F): 98
Temperature (C): 36.7
Temp Method: Option “Oral” is selected.
Right sidebar (Add Progress Note panel):
Title: “Add Progress Note – Standard Vitals”
Note text: “Vitals collected per protocol prior to IP administration. BP, HR, RR, Temp, and SpO₂ recorded. Participant was seated for 5 minutes prior to measurements. No abnormalities noted.”
Draft status: “Draft started on 21-MAY-2025 3:23 PM EDT”
Buttons at bottom: “Save Draft,” “Publish,” and “Cancel”

40% higher enrollment
40% faster site startup
90% monitoring productivity gain

Schedule a Demo Now

As a tech-enabled, virtual CRO, we have incorporated CRIO as a core technology to deliver streamlined and compliant data for our sponsor clients. Our digital-first design philosophy, combined with CRIO’s site-centric approach, deliver unique value and faster timelines across virtual, hybrid, and traditional study structures.
Joel Morse, CEO, Curavit

CRIO has been a tremendous partner with Specialty Networks Research, especially in launching our prostate cancer registry across our nationwide network of urology practices. The system is easy to use for the research coordinators and allows our monitoring team to review the source data in real time, ensuring efficiency and consistent quality.
Lorraine O’Donnell, Director, SN Research

ClinCloud was excited to collaborate on a study that integrated eSource data and EDC. With this capability, our site and staff can focus more time on recruiting and retaining patients – what we do best.
Jessica Branning, CEO, ClinCloud

By using CRIO, we deliver significant value to our sponsor clients. CRIO standardizes data collection, eliminates avoidable errors, and allows our monitoring team to review the data continuously, letting us prevent deviations from recurring and improving patient safety.
Takoda Roland, Associate Vice President of Customer Success, Sitero

SEE CRIO IN ACTION

Your Central eSource for Faster, Smarter Decisions

CRIO’s Central eSource technology delivers tremendous site operational efficiency and unmatched clinical data accuracy.

Leverage Existing Site Technology

Many high-performing sites already use CRIO. Central eSource allows you to leverage these benefits across your entire trial at every site.

Build Compliance at the Source

Central eSource templates — configured and automated to your protocol — incorporate real-time alerts and run logic checks to ensure reliable endpoint data.

A photograph of a laptop on a desk displaying the CRIO “New eSource” Complete Physical Exam screen for “Demo Subject 001, Visit 1 – Screening” with Amelia Tian logged in. At the top is a dark header bar showing the eSource title, subject/visit info, and a “View Legend” button. A dark vertical sidebar on the left lists form sections—Informed Consent, Spanish Version, Demographics, Ht/Wt/BMI, Vitals, Medical/Surgical History, Prior/Concomitant Medications, Adverse Event Log, Serious Adverse Event Reporting Log, with “Complete Physical Exam” highlighted and “Targeted Physical Exam” below. The main panel is titled “Complete Physical Exam” and contains an instructions box (“If you perform a physical on another system, add a progress note indicating which. If you don’t examine any other systems, mark as NE (Not Examined).”) Below is a table of exam items (1. General appearance; 2. Dermatological; 3. Head/Neck (including thyroid); 4. Ears, Nose, Throat; 5. Eyes; 6. Neurological; 7. Respiratory; etc.) with four radio-button columns: Normal (all currently selected), Abnormal NCS, Abnormal CS, and Not Examined. In the foreground, a hand holding a pen hovers above the keyboard. A window and a coffee cup sit in soft-focus behind the laptop.

CRIO-powered sites out-enroll others by 40% and have 2x the patient diversity.

Close-up of two healthcare professionals collaborating at a laptop, with one typing and the other pointing at the screen, indicating teamwork in a clinical or medical setting.

CRIO-powered studies reduce costs by 50%.

Review Data Immediately and Continuously

A centralized, fully remote, and continuous review process captures deviations early and delivers insights sooner.

Empower Your Sites

Central eSource and site configurability reduce your site’s administrative burden, improving enrollment, accelerating startup, and freeing them to focus on patients.

Get EDC Data Faster With Fewer Queries

Configure your Central eSource template to match your eCRF, integrate with leading EDC vendors, and enable sites to automate data transmission.

Save Big

Real-time source data access and seamless EDC integration — with our EDC solution or with top vendors — substantially decrease on-site monitoring time, reduce source data verification, and cut travel costs.